Gavin Sheets hit two of San Diego's four home runs and drove in four runs, and Fernando Tatis Jr. robbed San Francisco's Rafael Devers of a homer as the Padres beat the Giants 8-1 on Wednesday night.

Yusei Kikuchi threw seven strong innings, Luis Rengifo hit a tiebreaking RBI single in the eighth and the Los Angeles Angels beat the Cincinnati Reds 2-1 on Wednesday night.

Hunter Goodman had three hits and three RBIs, Tanner Gordon gave up one run in six innings, and the MLB-worst Colorado Rockies roughed up Shohei Ohtani in his first pitching start at Coors Field in an 8-3 victory over the Los Angeles Dodgers on Wednesday night.

Shea Langeliers hit a two-run homer in the 10th inning and the Athletics beat the Minnesota Twins 4-2 on Wednesday night.

Giancarlo Stanton hit a pinch-hit, two-run home run in the top of the 10th inning to lift the Yankees to a 6-4 win over the Tampa Bay Rays on Wednesday night.

Kyle Higashioka had a three-run double in the ninth inning after a two-out error by Vinnie Pasquantino, and the Texas Rangers rallied to beat the Kansas City Royals 6-3 on Wednesday night.

Los Angeles Dodgers two-way star Shohei Ohtani had a forgettable outing in his first career pitching start against the Colorado Rockies at Coors Field. Ohtani left Wednesday's game after giving up five earned runs and nine hits in four innings and batting in the fifth inning.

Michael Busch hit a three-run double off Jacob Misiorowski, and the Chicago Cubs beat the Milwaukee Brewers 4-3 on Wednesday night for their third consecutive victory over the NL Central leaders.

Cubs right fielder Kyle Tucker was diagnosed in June with a hairline fracture in his right hand, sources told ESPN on Wednesday.

Hurston Waldrep struck out a career best-tying seven in seven innings as the Atlanta Braves beat the Chicago White Sox 1-0 on Wednesday night.